Newsletters

[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.

[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.

[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.

[Cancer Research] Researchers used a convergence approach to identify tumor cell and cancer-associated fibroblast interactions through the integration of single-cell data from human tumors with human organoid coculture experiments.

[Journal Of Cell Biology] Through pharmacological and molecular manipulations in vitro, the authors reported that actomyosin-II inactivation diminished the reversible beading process, fostered progressive Ca2+ spreading and thereby increased acute axonal degeneration in stressed axons.

[Communications Biology] Using a multiomic approach, researchers analyzed epigenomic alterations of H3K27ac and global transcriptomic alterations sustained within a hypoxia and normoxia conditioned colorectal cancer cell line at 24 h following initial infection with F. nucleatum.

[Communications Biology] In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group.

[Development] Investigators used live imaging of the sea star embryo coupled with deep learning-based segmentation to dissect the relative contributions of cell density, tissue compaction, and cell proliferation on epithelial architecture.

[Journal Of Clinical Investigation] The authors investigated whether satellite cells could be derived in allogeneic or xenogeneic animal hosts.

[Journal Of Clinical Investigation] Scientists showed that the pathogenic SRSF2P95H/+ mutation disrupted the splicing of mitochondrial mRNAs, impaired mitochondrial complex I function, and robustly increased mitophagy.

[Cell Metabolism] Researchers demonstrated that cytochrome b (CYTB) also encoded an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code.

[Journal of Cell Biology] Investigators revealed the mechanism of heterochromatin targeting of histone H3 lysine36 dimethylation (H3K36me2). Among several H3K36 methyltransferases, NSD2 was responsible for inducing heterochromatic H3K36me2.