Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Advances in Targeted Therapy for Metastatic Prostate Cancer
[Current Treatment Options In Oncology] The authors highlight the role of poly-ADP-ribose-polymerase inhibitors in metastatic prostate cancer, emerging strategies to target the androgen receptor, and innovative therapies aimed at cell surface proteins, including radioligand therapies, bispecific T cell engagers, and antibody–drug conjugates.
Inflammatory Markers in Prostate Cancer: Potential Roles in Risk Stratification and Immune Profiling
[Journal of Immunotoxicology] Scientists evaluated the association between circulating and tissue inflammatory markers with prostate cancer presence and their potential as biomarkers for risk stratification.
A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy
[Cancer Research] Glutamine depletion reduced FOXM1 transcriptional occupancy on the promoter of fibroblast growth factor 8, a known mediator of prostate cancer castration resistance.
Catechin Designates Individual and Co-Adjuvant Antiproliferative Effects with Docetaxel in Prostate Cancer Cell Models
[Toxicology Research] Investigators examined the potential therapeutic advantages of catechin, either alone or in combination with docetaxel, against PC-3 prostate cancer cells.
PARP Inhibitor Response Is Enhanced in Prostate Cancer When XRCC1 Expression Is Reduced
[NAR Cancer] Researchers analyzed prostate cancer patients’ cohorts and found that XRCC1 expression varied widely, with many patients showing low XRCC1 expression.
Prostate cancer exploits BRD9-driven metabolic reprogramming to shape the aggressive phenotype
[Cell Death & Disease] Investigators identified Bromodomain-containing protein 9 (BRD9) as a metabolic checkpoint for reprogramming cell metabolism to support tumor growth and impart a castration-resistant phenotype under metabolic and oxidative stress.
SPOP Mutations Increase PARP Inhibitor Sensitivity via CK2/PIAS1/SPOP Axis in Prostate Cancer
[JCI Insight] Investigators found profound genomic instability in prostate cancer (PCa) cells with SPOP gene mutations and confirmed the sensitivity of SPOP-mutated PCa cells to olaparib-induced apoptosis.
ZIF-8/Doxorubicin Nanoparticles Camouflaged with Cucurbita-Derived Exosomes for Targeted Prostate Cancer Therapy
[Journal of Materials Chemistry B] Scientists designed a biomimetic nanocarrier composed of zeolitic imidazolate framework-8 (ZIF-8) encapsulating doxorubicin as the core and a shell of exosome-like nanoparticles derived from Cucurbita moschata. This design enhances safety and addresses some exosome limitations.
Valosin-Containing Protein (VCP/p97) Mediates Neuroendocrine Differentiation in Prostate Cancer Cells Through Pim1 Signaling Inducing Autophagy
[The Prostate] Investigators explored the molecular mechanisms through which valosin-containing protein/p97 contributes to the progression of neuroendocrine prostate cancer.
Stachydrine Hydrochloride Induces Cell Senescence and Ferroptosis of Castration-Resistant Prostate Cancer
[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists explored the potential of stachydrine hydrochloride in addressing paclitaxel resistance within castration-resistant prostate cancer.
The Role of Androgens and Global and Tissue-Specific Androgen Receptor Expression on Body Composition, Exercise Adaptation, and Performance
[Biology of Sex Differences] The authors summarize the understood mechanisms of action of androgen receptor (AR) and its interactions with exercise, specifically on outcomes of body composition and muscle function, and the global- and tissue-specific role of AR in regulating skeletal muscle, adipose, and bone morphology.
PSMA-Based Therapies and Novel Therapies in Advanced Prostate Cancer: The Now and the Future
[Current Treatment Options In Oncology] The future of mCRPC treatment likely lies in a personalized, multimodal approach that integrates PSMA-based RLTs, BiTEs, and complementary therapies at earlier disease stages.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
