Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
The Epigenetic Landscape of Mesenchymal Stem Cell and Extracellular Vesicle Therapy
[Trends In Cell Biology] The authors review epigenetic regulation of MSC and extracellular vesicle therapies, together with current challenges, aiming to deepen the understanding of donor–recipient communication and inspire next-generation approaches to counteract tissue defects and diseases.
Novel PEI-Aldehyde Conjugates for Gene Delivery: Promoting Chondrogenic Differentiation in Human Mesenchymal Stem Cells
[Molecular Therapy - Nucleic Acids] Researchers explored the development of novel polyethyleneimine (PEI)-based polymers functionalized with both cationic guanidinium and hydrophobic aldehyde groups for efficient transfection to human MSCs.
Combinatorial Extracellular Matrix Tissue Chips for Optimizing Mesenchymal Stromal Cell Microenvironment and Manufacturing
[NPJ Regenerative Medicine] Researchers developed tissue chips to study the effects of multi-factorial extracellular matrix (ECM) environments under manufacturable stiffness ranges and multi-component ECM compositions.
NUP62 Alleviates Senescence and Promotes the Stemness of Human Dental Pulp Stem Cells via NSD2-Dependent Epigenetic Reprogramming
[International Journal of Oral Science] Researchers conducted a proteomic analysis of human dental pulp stem cells obtained from individuals of various ages. They discovered that NUP62 alleviated senescence-associated phenotypes and enhanced differentiation potential both in vitro and in vivo.
Autophagy Inhibition Enhances Antifibrotic Potential of Placental Mesenchymal Stem Cells of Fetal Origin via Regulating TGF-β1 Mediated Protein Degradation of HGF
[Scientific Reports] Scientists investigated how the pulmonary fibrosis pathological microenvironment modulated the antifibrotic potential of placental MSCs of fetal origin through hepatocyte growth factor regulation.
Reliable Harvest of Injectable Human Mesenchymal Stem Cell Sheets by Modulating Cell-Substrate Adhesion Strength
[Advanced Healthcare Materials] Scientists addressed a reliable method for controlling cell sheet dimensions by combining differential cell adhesion-guided micropatterning along with an isothermal detachment method.
The Role of Mesenchymal Stem Cell‑Derived Exosomes in Asthma
[Molecular Medicine Reports] The authors explore the therapeutic potential of MSC‑derived exosomes in asthma, highlighting their ability to modulate key pathological mechanisms underlying the disease.
Exploring the Mechanism of Bone Marrow Mesenchymal Stromal Cell Exosomes in Respiratory Syncytial Virus Infection Based on miRNA Sequencing
[Scientific Reports] In vivo experiments demonstrated that exosomes from respiratory syncytial virus (RSV)-treated bone marrow MSCs enhanced the inflammatory response in RSV-infected mice, indicated by elevated serum inflammatory cytokines, lung dysfunction, airway inflammation, and increased mucus secretion.
BDNF-GABA Signaling in Astrocytes: Enhancing Neural Repair after SCI through MSC Therapies
[Spinal Cord] hUC-MSCs were found to enhance neural repair by activating BDNF-regulated GABA signaling of astrocytes.
Sequential Infusion of Mesenchymal Stem Cell for Graft-Versus-Host Disease Prevention in Haploidentical Hematopoietic Stem Cell Transplantation: An Open-Label, Multicenter, Randomized Controlled Clinical Trial
[Journal of Clinical Oncology] This open-label, multicenter, randomized controlled trial explored the efficacy and safety of sequential umbilical cord–derived MSC infusion for graft-versus-host disease prevention within 3 months of haploidentical HSC transplantation.
SynOx Therapeutics Receives Fast Track Designation from US FDA for Emactuzumab for Tenosynovial Giant Cell Tumours (TGCT)
[SynOx Therapeutics] SynOx Therapeutics announced that the US FDA has granted Fast Track Designation to emactuzumab for the treatment of TGCT patients that are not amenable to or who would not benefit from surgery.
Tracing Genomic Instability in Induced Mesenchymal Stromal Cell Manufacture: An Integration-Free Transfection Approach
[British Journal of Cancer] Scientists investigated the genomic changes occurring during the process of generating and passaging iPSCs and differentiating them into iPSC-derived mesenchymal stem cells (iMS), as well as the changes that occured during iMS cell passage.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
