Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Deconvoluting TCR-Dependent and -Independent Activation Is Vital for Reliable Ag-Specific CD4+ T Cell Characterization by AIM Assay
[Science Advances] Researchers showed that CD39+ regulatory T cell (Treg)–like and CD26hi TH22–like cells undergo T cell receptor–independent activation by cytokines during antigen stimulation, leading to nonspecific up-regulation of activation-induced marker readouts.
Regulatory T Cell Memory: Implications for Malaria
[The Journal of Immunology] The authors explore the biology of Treg memory, with a focus on malaria, and examine the immunological implications of maintaining a suppressive mTreg population in malaria immunity.
Prospective Analysis of the Number and Function of Two T Regulatory Cell Subsets in Healthy Individuals
[Clinical & Experimental Immunology] Investigators analyzed potential variations in the number and function of two Treg cell subsets in healthy adults over a two-month period.
The TRIB2-DNMT1 Pathway Generates an Immune Cold Microenvironment in Glioblastoma and Its Inhibition Promotes Immunotherapy
[Cancer Immunology Research] Investigators identified regulators of low CD8+ T-cell infiltration in glioblastoma (GBM). Using transcriptomic screening, they found that TRIB2 was a regulator of the immune-cold microenvironment characteristic of GBM.
An Oncolytic Vaccinia Virus Expressing Anti-CD47 Nanobody Exerts Enhanced Antitumor Activity by Mediating Innate and Adaptive Immune Cell Infiltration and Activation in the Lymphoma...
[Haematologica] Arming oncolytic vaccine virus with a CD47-blocking nanobody and IgG1 Fc created a dual-functional therapeutic platform, offering a paradigm-shifting strategy for lymphoma immunotherapy through coordinated innate and adaptive immune activation.
H3K27M Diffuse Midline Glioma Is Homologous Recombination Defective and Sensitized to Radiotherapy and NK Cell-Mediated Antitumor Immunity by PARP Inhibition
[Neuro-Oncology] Homologous recombination repair deficiency in histone H3 lysine 27-to-methionine diffuse midline glioma (H3K27M DMG) can be therapeutically leveraged with PARP inhibitors to radiosensitize and induce an NK cell-mediated antitumor immune response selectively in H3K27M DMG, supporting the clinical investigation of PARP1 inhibitors with radiotherapy in DMG patients.
Ad-SGE-DKK3 Gene Therapy Overcomes Resistance to Immune Checkpoint Blockade in Pleural Mesothelioma
[Clinical Cancer Research] Researchers performed preclinical studies to elucidate Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3)’s role in immune checkpoint inhibitors-resistant mouse mesothelioma.
IL-12-Producing Cytokine Factories Induce Precursor Exhausted T Cells and Elimination of Primary and Metastatic Tumors
[Journal for ImmunoTherapy of Cancer] Researchers evaluated the safety and antitumor efficacy of locally administered interleukin 12 (IL-12) using a clinically translatable cytokine delivery platform to identify Tpex recruitment capabilities at tolerable cytokine doses.
Targeted Release of a Bispecific Fusion Protein SIRPα/Siglec-10 by Oncolytic Adenovirus Reinvigorates Tumor-Associated Macrophages to Improve Therapeutic Outcomes in Solid Tumors
[Journal for ImmunoTherapy of Cancer] To identify the characteristics of recombinant adenovirus-SIRPα/Siglec-10, investigators conducted CCK8 assay, quantitative PCR, western blot, competitive binding assay, in vitro cytotoxicity assay, ELISA and phagocytosis assay.
Memory-Like Natural Killer Cell and CD19-Antibody Based Immunotherapy in Combination with Tyrosine-Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia
[Cancer Immunology Research] Investigators explored the potential of memory-like natural killer cells and Fc-enhanced CD19-ADCC in combination with tyrosine kinase inhibitor directed against kinase-driven leukemia models, including patient-derived xenografted Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL).
In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type Ⅰ Interferon Signaling in Monocytes
[Cancer Immunology Research] Investigators synthetized mRNA encoding gasdermin E (GSDME) encapsulated by lipid nanoparticles (LNP-Gsdme). In situ delivery of LNP-Gsdme through intratumoral injection suppressed tumor growth, boosted monocyte infiltration and activated CD8+T cells.
Cxcr3 Promotes Protection from Colorectal Cancer Liver Metastasis by Driving NK Cell Infiltration and Plasticity
[Journal of Clinical Investigation] Researchers investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+NK cell population within the liver metastasis environment of colorectal cancer.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
