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Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
Metabolism-Driven Posttranslational Modifications and Immune Regulation: Emerging Targets for Immunotherapy
[Science Advances] Advances in mass spectrometry and bioinformatics now enable precise characterization of metabolite-derived posttranslational modifications, uncovering their broad roles in immune regulation.
The Protective Role of TIGIT+ B Cells in Attenuating Type 1 Diabetes Progression
[Diabetes Obesity & Metabolism] The authors investigated the expression, functional, and metabolic characteristics of T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) + B cells in type 1 diabetes patients and non-obese diabetic mice using flow cytometry.
Simultaneous STING and lymphotoxin-β Receptor Activation Induces B Cell Responses in Tertiary Lymphoid Structures to Potentiate Antitumor Immunity
[Nature Immunology] Investigators showed that simultaneous activation STING and lymphotoxin-β receptor results in CD8+ T cell-dependent tumor suppression while inducing high endothelial venule development and germinal center-like B cell responses in tumors to generate functional tertiary lymphoid structures in a T cell-dependent manner.
UBA1-Depleted Neutrophils Disrupt Immune Homeostasis and Induce VEXAS-Like Autoinflammatory Disease in Mice
[Journal of Clinical Investigation] Researchers reported that loss of Uba1 in various mouse hematopoietic cell types resulted in pleiotropic consequences and demonstrated that murine mutants with about 70% loss of Uba1 in neutrophils induced non-lethal vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS)-like symptoms.
Immune Cell Quantification of In Situ Inflammation Partitions Human Lupus Nephritis into Mechanistic Subtypes
[Journal of Clinical Investigation] Scientists used high-dimensional confocal microscopy, spatial transcriptomics, and specialized computer vision techniques to quantify immune cell populations and localize these within normal and diseased renal cortex structures.
Follicular Regulatory T Cells Promote Experimental Autoimmune Encephalomyelitis by Supporting B Cell Egress from Germinal Centers
[Science Translational Medicine] The authors quantified peripheral blood immune subpopulations in two cohorts of patients with multiple sclerosis and found higher circulating follicular regulatory T cells cell frequencies in patients in relapse compared with patients in remission.
ENPP1 Inhibitor with Ultralong Drug-Target Residence Time As an Innate Immune Checkpoint Blockade Cancer Therapy
[Cell Reports Medicine] Investigators reported the characterization of STF-1623, a highly potent ectonucleotide pyrophosphatase/phophodiesterase 1 (ENPP1) inhibitor with an exceptionally long tumor residence time despite rapid systemic clearance, enabled by its high ENPP1 binding affinity and slow dissociation rate.
Engineered Immunoagonist Non-Coding RNA (incRNA) Activates Dual TLR Pathways for Cancer Immunotherapy
[Advanced Healthcare Materials] Scientists challenged the necessity of extensive mRNA modification as a universal strategy by introducing ‘immunoagonist non-coding RNA (incRNA)’, a new class of RNA therapeutic that exploits innate immune activation rather than evading it.
Pseudouridine Synthase 1-Targeted Therapy Activates Antiviral Immunity to Boost Cancer Immunotherapy
[Cell Reports] Researchers identified pseudouridine synthase 1 (PUS1) as a key driver of tumor immune evasion. They found that PUS1 is aberrantly overexpressed in tumors and correlates with tumor malignant progression.
Atg7 in CD4+ T Cells Improves Intestinal Mucosal Inflammation by Regulating Ets1-Mediated T Cell Differentiation
[Clinical and Translational Medicine] qRT-PCR, western blotting analysis, flow cytometry, and immunohistochemistry were employed to evaluate ATG7 expression in peripheral blood and colonic mucosal biopsies from inflammatory bowel disease patients.
Shengxian Decoction Alleviates Experimental Autoimmune Myasthenia Gravis by Enhancing the Immunosuppressive Activity of Regulatory T Cells via Hippo Pathway
[Journal of Ethnopharmacology] Employing prednisone as a positive control, the experimental autoimmune myasthenia gravis rat model induced by recombinant acetylcholine receptor α subunit 97–116 peptide was used to reveal and confirm the therapeutic effect of Shengxian Decoction on Myasthenia gravis.
Immune-Cell Profiling to Guide Stratification and Treatment of Patients with Rheumatic Diseases
[Nature Reviews Rheumatology] Cellular immune profiling enables the identification of specific features of immune dysregulation in individuals with rare, undiagnosed, inflammatory diseases.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
