Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Possible Impacts of Cosmic Radiation on Leukemia Development during Human Deep Space Exploration
[Leukemia] The authors provide a comprehensive review of the various studies and evidence available on Earth and in space assessing the relationship between ionizing radiation and increased risk of leukemia.
The Mitochondrial Protease ClpP Is a Metabolic Vulnerability and an Immunogenic Trigger against Multiple Myeloma.
[Blood] Scientists showed that the mitochondrial protease ClpP is both a cell-intrinsic metabolic vulnerability and an actionable immunogenic trigger in multiple myeloma.
The Protein Deacetylase HDAC10 Controls DNA Replication in Malignant Lymphoid Cells
[Leukemia] Researchers demonstrated that human cultured and primary acute B cell/T cell leukemia and lymphoma cells required the catalytic activity of HDAC10 for their survival.
Hematopoietic Stem Cell Transplantation Outcomes for High-Risk AML: A Report From the Children’s Oncology Group
[Journal of Clinical Oncology] Researchers conducted a cross-study analysis to determine whether HSC transplantation improves the outcomes of patients with contemporarily defined high-risk AML.
Venetoclax Plus Modified-Intensity Idarubicin and Cytarabine Treatment As First-Line Treatment for Newly Diagnosed Pediatric Acute Myeloid Leukemia
[Clinical Cancer Research] In an open-label, single-arm, multi-center prospective clinical trial, 65 newly diagnosed AML pediatric patients received venetoclax and modified-intensity cytarabine and idarubicin.
Mis-Splicing-Derived Neoantigens and Cognate TCRs in Splicing Factor Mutant Leukemias
[Cell] Researchers utilized feature-barcoded peptide-major histocompatibility complex dextramers to isolate neoantigen-reactive T cell receptors from healthy donors, patients with active myeloid malignancy, and following curative allogeneic stem cell transplant
An Oncolytic Adenovirus Targeting SLAMF7 Demonstrates Anti-Myeloma Efficacy
[Leukemia] Researchers investigated a novel SLAMF7-promoter driven oncolytic adenovirus as a potential therapeutic for multiple myeloma, an incurable hematological malignancy.
Heterogeneity of High-Potency Multilineage Hematopoietic Stem Cells and Identification of ‘Super’ Transplantability
[Blood] Scientists conducted large-scale single-clone serial-transplant experiments and tracked descendant cells of 288 HSC clones to quantify their intrinsic capability for hematopoietic reconstitution.
Orchestration of Human Multi-Lineage Hematopoietic Cell Development by Humanized In Vivo Bone Marrow Models
[Hemasphere] Researchers thoroughly characterized a humanized in vivo bone marrow model, developed from fetal and post-natal mesenchymal stromal cell differentiation, in which human hematopoietic cells were generated following the transplantation of CD34+ cells.
Microbial Metabolite Drives Aging-Related Clonal Hematopoiesis via ALPK1
[Nature] Investigators showed that intestinal alterations, which can occur with age, led to systemic dissemination of a microbial metabolite that promoteed pre-leukemic cell expansion.
A Phase I / IIa Trial of PXS-5505, a Novel Pan-Lysyl Oxidase Inhibitor, in Advanced Myelofibrosis
[Haematologica] PXS5505-MF-101 was a multi-center Phase I/IIa study of PXS-5505 in myelofibrosis patients which included a dose escalation phase and a cohort expansion phase.
Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes: A Practical Guide to Diagnosis and Management
[Leukemia] Scientists provide a practical guide for the diagnosis and management of myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
