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Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Antigenicity Assessment of SARS-CoV-2 Saltation Variant BA.2.87.1
[Emerging Microbes & Infections] Investigators elucidated the antigenic characteristics and immune evasion capability of BA.2.87.1. Our findings revealed that BA.2.87.1 was more susceptible to XBB-induced humoral immunity compared to JN.1.
Computationally Restoring the Potency of a Clinical Antibody Against Omicron
[Nature] The authors showed that their computationally redesigned antibody, 2130-1-0114-112, simultaneously increased neutralization potency against Delta and subsequent variants of concern, and provides protection in vivo against the strains tested: WA1/2020, BA.1.1 and BA.5.
Neuropathological Assessment of the Olfactory Bulb and Tract in Individuals With COVID-19
[Acta Neuropathologica Communications] Using semiquantitative measurements of immunohistochemical signals, we examined olfactory bulbs and olfactory tract specimens collected serially at autopsies between 2020 and 2023.
Study of Cow Tissues Provides Clues for Unusual Pattern of Bird Flu Infections in Dairy Cattle
[STAT News] A new study looking at the distribution of receptors that flu viruses can attach to in different cow tissues may help to explain the pattern of illness being seen in the outbreak of H5N1 bird flu in US dairy cattle — and also is sparking debate about the implications of the cow outbreak for human disease.
Feds Put $15M Into Pathogen Tracking, Health-Care Supply Chain Research to Prep for Next Pandemic
[CBC] A new $15-million cross-border research project is underway to monitor the movement of pathogens in Canada and the US in the event of future pandemics.
Designing a Smallpox B-Cell and T-Cell Multi-Epitope Subunit Vaccine Using a Comprehensive Immunoinformatics Approach
[Microbiology Spectrum] The authors designed a peptide vaccine using immunoinformatics tools, which have the potential to activate human immunity against variola virus infection efficiently. The design of peptides derives from vaccine-candidate proteins showing protective potential in vaccinia WR strains.
Inhibition of Caspase Pathways Limits CD4+ T Cell Loss and Restores Host Anti-Retroviral Function in HIV-1 Infected Humanized Mice With Augmented Lymphoid Tissue
[Retrovirology] Researchers utilized exogenous injection of the human recombinant FMS-like tyrosine kinase 3 ligand into the hematopoietic stem cell cord blood human immune system mouse model to significantly expand the total area of lymph node and the number of circulating human T cells.
Predicting Vaccine Effectiveness for Mpox
[Nature Communications] Investigators performed a systematic search and meta-analysis of the available data to test whether vaccinia-binding ELISA endpoint titer is predictive of vaccine effectiveness against mpox.
Doxycycline Protects Against Sepsis-Induced Endothelial Glycocalyx Shedding
[Scientific Reports] Rats that received pretreatment with doxycycline before lipopolysaccharide displayed ultrastructural preservation of the endothelial glycocalyx observed using transmission electronic microscopy of the lung and heart.
Epigenetic Reprograming in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Narrative of Latent Viruses
[Journal Of Internal Medicine] Investigators provide an overview of the epigenetic signatures demonstrated in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) and focus on the potential strategies that latent viruses—particularly Epstein–Barr virus—may employ in long-term epigenetic reprograming in ME/CFS.
The Effect of COVID-19 Vaccination on Outpatient Antibiotic Prescribing in Older Adults: A Self-Controlled Risk-Interval Study
[Clinical Infectious Diseases] Researchers assessed the impact of COVID-19 vaccination on outpatient antibiotic prescribing in the broader population of older adults, regardless of SARS-CoV-2 infection status.
Integrating Population and Single-Cell Variations in Vaccine Responses Identifies a Naturally Adjuvanted Human Immune Setpoint
[Immunity] Investigators introduce a framework to integrate variations at the human population and single-cell levels in vaccination responses.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
