NewslettersDermal Cell News VDAC1 Negatively Regulates Melanogenesis through the Ca2+-Calcineurin-CRTC1-MITF Pathway By mladbrook - June 6, 2022 0 Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway. [Life Science Alliance] Full Article