NewslettersCancer Stem Cell NewsHematopoiesis News The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem and Progenitor Cells to Maintain Stemness By Danielle Corrigan - June 8, 2022 0 Overexpression of nuclear HK2 increased leukemic stem cell properties and decreased differentiation, whereas selective nuclear HK2 knockdown promoted differentiation and decreased stem cell function. [Nature Cell Biology] Full Article