NewslettersImmune Regulation News Fumarate Suppresses B Cell Activation and Function through Direct Inactivation of LYN By Danielle Corrigan - June 17, 2022 0 The authors demonstrated that B Cell activation reprogramed the tricarboxylic acid cycle and boosted the expression of fumarate hydratase, leading to decreased cellular fumarate abundance. [Nature Chemical Biology] AbstractGraphical Abstract