Genomic, Transcriptomic, and Metabolomic Profiles of hiPSC-Derived Dopamine Neurons from Clinically Discordant Brothers with Identical PRKN Deletions

Scientists differentiated human-induced pluripotent stem cells (hiPSCs) derived from the two brothers into mesencephalic neural precursor cells and early postmitotic dopaminergic neurons and performed wholeexome sequencing and transcriptomic and metabolomic analyses.