NewslettersHuman Immunology News Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Antitumor Immunity By Danielle Corrigan - July 12, 2022 0 Patients with POLE/POLD1 mutated tumors harboring telltale mutational signatures responded better to immune checkpoint blockade therapy than patients harboring wild-type or signature-negative tumors. [Nature Genetics] Abstract