NewslettersHematopoiesis News Lack of COL6/Collagen VI Causes Megakaryocyte Dysfunction by Impairing Autophagy and Inducing Apoptosis By mladbrook - July 21, 2022 0 Researchers demonstrated by in vitro and in vivo approaches that megakaryocytes derived from col6a1−⁄− null mice display increased intracellular retention of COL6 polypeptides, endoplasmic reticulum stress and apoptosis. [Autophagy] Abstract