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eIF2Bδ Blocks the Integrated Stress Response and Maintains eIF2B Activity and Cancer Metastasis by Overexpression in Breast Cancer Stem Cells

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Scientists described a unique translation regulatory axis enacted by reduced expression of miR-183 in breast CSCs, which they showed targeted the eIF2Bδ subunit of guanine nucleotide exchange factor eIF2B.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]
Abstract
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