The DACH1 Gene Is Frequently Deleted in Prostate Cancer, Restrains Prostatic Intraepithelial Neoplasia, Decreases DNA Damage Repair, and Predicts Therapy Responses

In prostate OncoMice, prostate-specific deletion of the Dach1 gene enhanced prostatic intraepithelial neoplasia, and was associated with increased transforming growth factor β activity and DNA damage.