NewslettersHuman Immunology News Metabolic Reprogramming via ACOD1 Depletion Enhances Function of Human Induced Pluripotent Stem Cell-Derived CAR-Macrophages in Solid Tumors By Bob - September 19, 2023 0 Scientists found, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 were strong regulators of the pro-inflammatory state in macrophages. [Nature Communications] Full Article