NewslettersDermal Cell News Increase of ISG15 in Psoriasis Lesions and Its Promotion of Keratinocyte Proliferation via the Hif-1α Signaling Pathway By Bob - September 25, 2023 0 The expression of interferon stimulated gene 15 (ISG15) saw a significant increase through the immunohistochemical detection of imiquimod-induced mice. In the psoriasis cell model, a remarkable increase also occurred. [Experimental Dermatology] Abstract