Circ-Hdgfrp3 Shuttles along Neurites and Is Trapped in Aggregates Formed by ALS-Associated Mutant FUS

Investigators defined several features of circ-Hdgfrp3 and described interesting alterations occurring in motor neurons carrying ALS-associated FUS mutations. Through a highly sensitive in situ approach they described that circ-Hdgfrp3 trafficked along neurites, whilst upon oxidative stress it was retained in the perinuclear region.