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Anti-CAIX BBζ CAR4/8 T Cells Exhibit Superior Efficacy in a Clear Cell Renal Cell Carcinoma (ccRCC) Mouse Model

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The authors compared second-generation with third-generation carbonic anhydrase IX targeted CAR constructs and investigated the anti-tumor effect of CAR-T cells with different CD4/CD8 proportions in vitro and in vivo.
[Molecular Therapy Oncolytics]

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