Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Preclinical Targeting of Leukemia-Initiating Cells in the Development Future Biologics for Acute Myeloid Leukemia
[Expert Opinion On Therapeutic Targets] The authors summarize preclinical advances in targeting acute myeloid leukemia leukemia-initiating cells, including strategies to exploit metabolic vulnerabilities, such as the reliance on oxidative phosphorylation.
Different Features of Acute Myeloid Leukemia Stem Cell Quantification in Intensively Treated Patients
[Haematologica] Since different methods of leukemic stem cell quantification have been proposed, scientists determined the prognostic value on overall survival and incidence of relapse of these methods across ELN2017 risk groups, using data from the HOVON-SAKK132 trial.
SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling
[Advanced Science] Scientists revealed that the voltage-gated calcium channel subunit α2δ1-mediated calcium signaling can upregulate the expression of SIRT4, which is highly expressed in α2δ1-positive pancreatic tumor-initiating cells.
A Novel Model of Glioblastoma Recurrence to Identify Therapeutic Vulnerabilities
[EMBO Molecular Medicine] Researchers designed and characterized a novel induced-recurrence model in which mice xenografted with primary patient-derived glioma initiating/stem cells are treated with a therapeutic regimen closely recapitulating patient standard of care, followed by monitoring until tumours recur.
NR2F2 and Its Contribution to Lymph Node Metastasis in Oral Squamous Cell Carcinoma
Investigators explored the role of CSCs in lymph node metastasis of oral squamous cell carcinoma, focusing on the expression and biological significance of nuclear...
Asymmetric Cell Division of ALDH1-Positive Cancer Stem Cells Generates Glycolytic Metabolically Diverse Cell Populations
Researchers revealed that PKCλ-dependent asymmetric division of ALDH1-positive CSCs led to an uneven distribution of glycolytic capacity, which was crucial for understanding metabolic heterogeneity...
NCAPH Promotes Glucose Metabolism Reprogramming and Cell Stemness in Ovarian Cancer Cells through the MEK/ERK/PD-L1 Pathway
Researchers observed that non-structural maintenance of chromosomes condensin I complex subunit H (NCAPH) expression was upregulated in ovarian cancer cells. Silencing NCAPH led to...
Cancer Stem Cells-Derived Exosomal TSPAN8 Enhances Non-Stem Cancer Cells Stemness and Promotes Malignant Progression in PDAC
[Oncogene] Investigators employed single-cell RNA sequencing and exosomal profiling, identifying TSPAN8-enriched exosomes secreted by CSC, which were associated with poor survival rates in pancreatic ductal adenocarcinoma patients.
CD44: A Key Regulator of Iron Metabolism, Redox Balance, and Therapeutic Resistance in Cancer Stem Cells
[Stem Cells] The authors highlight the multifaceted roles of CD44 in CSC biology, focusing on its contribution to ferroptosis resistance, iron metabolism, and redox regulation.
Risk of Recurrence and Cancer Stem Cell Marker CD133 Expression Vary in Males Versus Females with Papillary Thyroid Cancer
[Annals of Surgical Oncology] Scientists defined the association between CD133 expression in papillary thyroid cancer and recurrence-free survival
Modulating Cancer Stem Cell Characteristics in CD133+ Melanoma Cells through Hif1α, KLF4, and SHH Silencing
[ACS Omega] Scientists examined how silencing three key genes─Hif1α, KLF4, and SHH─affects CSC characteristics.
Angiogenesis Causes and Vasculogenic Mimicry Formation in the Context of Cancer Stem Cells
[Biochimica Et Biophysica Acta-Reviews On Cancer] The authors summarize the role of vascular niche formed by angiogenesis in CSC self-renewal and stemness maintenance, and the function of CSCs in endothelial progenitor cell differentiation and pro-angiogenic factor upregulation.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
