Hepatic Cell News
Hepatic Cell News is an online resource covering the top research on hepatocytes and liver diseases.
Type I MET Inhibitors Cooperate with PD-1 Blockade to Promote Rejection of Hepatocellular Carcinoma
[Journal for ImmunoTherapy of Cancer] The authors investigated across the Hepa1-6, HCA-1 and diethylnitrosamine models of hepatocellular carcinoma whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with PD-1 blockade.
Luteolin Detoxifies DEHP and Prevents Liver Injury by Degrading Uroc1 Protein in Mice
[EMBO Molecular Medicine] By developing a Cy5-modified single-strand DNA-aptamer-based approach targeting di-(2-ethylhexyl) phthalate (DEHP), the authors identified luteolin as a potential drug, which showcasing robust efficacy in detoxifying the DEHP by facilitating the expulsion of DEHP in both mouse primary hepatocytes and livers.
METTL3 Confers Oxaliplatin Resistance Through the Activation of G6PD-Enhanced Pentose Phosphate Pathway in Hepatocellular Carcinoma
[Cell Death & Differentiation] Employing siRNA library screening, scientists identified that silencing the m6A writer methyltransferase-like 3 (METTL3) significantly enhanced the sensitivity to oxaliplatin in both in vivo and in vitro hepatocellular carcinoma models.
N6-Methyladenosine (m6A) Modification Activates Serine Synthesis Pathway to Mediate Therapeutic Resistance in Liver Cancer
[Molecular Therapy] Using GLORI-seq, scientists delineated a single-base resolution m6A landscape in human HCC cell lines. They identified three core enzymes in the serine synthesis pathway as novel targets of METTL3-mediated m6A modification.
The Nr4a Family Regulates Intrahepatic Treg Proliferation and Liver Fibrosis in MASLD Models
[Journal of Clinical Investigation] Scientists found an increase of Nr4a family of orphan nuclear receptors expression in intrahepatic T cells from mice with diet-induced nonalcoholic steatohepatitis (NASH). Loss of Nr4a1 and Nr4a2 in T cell ameliorated liver cell death and fibrosis, thereby mitigating liver dysfunction in NASH mice.
Multi-Omic Analysis Identifies the Molecular Mechanism of Hepatocellular Carcinoma with Cirrhosis
[Scientific Reports] RNA-sequencing data and corresponding clinical features of patients with HCC were extracted from The Cancer Genome Atlas database using the University of California Santa Cruz Xena platform.
Hepatocyte Apoptosis Is Triggered by Hepatic Inflammation in Common Carp Acutely Exposed to Microcystin-LR or Chronically Exposed to Microcystis
[Ecotoxicology and Environmental Safety] Investigators investigated the mechanism underlying the hepatic inflammatory response and hepatocyte apoptosis induced by acute microcystin-LR exposure via intraperitoneal injection or gavage and chronic exposure to toxic Microcystis blooms.
microRNA-2117 Negatively Regulates Liver Cancer Stem Cells Expansion and Chemoresistance Via Targeting SOX2
[Molecular Carcinogenesis] Researchers showed that miR-2117 was downregulated in liver cancer stem cells (CSCs) and predicted the poor prognosis of hepatocellular carcinoma patients. Biofunction studies found that knockdown miR-2117 facilitates liver CSCs self-renewal and tumorigenesis.
Curcumin-Encapsulated Glucan Nanoparticles as an Oxidative Stress Modulator Against Human Hepatic Cancer Cells
[Colloids and Surfaces B-Biointerfaces] Scientists explored the encapsulation of curcumin in glucan nanoparticles (NPs) and its impact on oxidative stress in liver cancer cells. Smaller GC111 NPs were promising candidates for future studies aimed at evaluating oxidative stress-induced tumor cell death mechanisms.
Delphinidin or α-Amyrin Attenuated Liver Steatosis and Metabolic Disarrangement in Rats Fed a High-Fat Diet
[Biofactors] Investigators assessed the therapeutic impacts of delphinidin, an anthocyanin, or α-amyrin, a pentacyclic triterpenoid, on non-alcoholic fatty liver disease in rats and the underlying mechanisms involved.
Thyroid Hormone Receptor-β Analogs for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH)
[Journal of Hepatology] The most advanced compound, resmetirom, is an oral drug that demonstrated, in a large Phase III trial in MASH patients, the ability to remove liver fat, reduce aminotransferase levels and improve atherogenic dyslipidemia with a good tolerability profile.
Nano-Encapsulation of Drugs to Target Hepatic Stellate Cells: Toward Precision Treatments of Liver Fibrosis
[Journal of Controlled Release] Scientists present a brief overview of the role of hepatic stellate cells (HSCs) in the pathogenesis of liver fibrosis, summarize the different types of nanocarriers and their specific delivery applications in liver fibrosis, and highlight the biological barriers associated with the use of nanosystems to target HSCs and approaches available to solve this issue.
The publications featured in Hepatic Cell News are expertly selected by our in-house editorial team from high impact, peer-reviewed academic journals. We cover areas including the culturing and characterization of hepatocytes, liver stem cells, and the pathogenesis of conditions such as liver cirrhosis and hepatocellular carcinoma. Additionally, we provide the latest updates on broader news, upcoming events, and job postings to keep the global liver research community connected!
