Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

Tumor Organoids Improve Mutation Detection of Pancreatic Ductal Adenocarcinoma

[Scientific Reports] Researchers investigated the utility of patient-derived organoids (PDOs) to overcome the obstacles of detecting somatic mutations and enhance somatic mutation identification. Surgically resected pancreatic ductal adenocarcinoma tumors and their paired PDOs from 21 patients were examined.

Age-Associated Imbalance in Immune Cell Regeneration Varies Across Individuals and Arises from a Distinct Subset of Stem Cells

[Cellular & Molecular Immunology] The authors used high-throughput single-cell technologies to compare mice of the same chronological age that exhibited early or delayed immune aging phenotypes.

Inflammation-Responsive Polyion Complex Vesicles for Autoimmune Disease Therapy via Cell-Free DNA Scavenging and Inflammatory Microenvironment Modulation

[ACS Nano] Inflammation-responsive polyion complex vesicles were developed, bridging inflammation-instructed cfDNA scavenging, and methotrexate delivery for autoimmune disease management.

Targeting Unc5b in Macrophages Drives Atherosclerosis Regression and Pro-Resolving Immune Cell Function

[Proceedings of The National Academy of Sciences of The United States of America] Investigators tested the therapeutic potential of deleting Unc5b in mice with advanced atherosclerosis. They generated Unc5bfl/flCx3cr1creERT2/WT mice, which allowed conditional deletion of Un5b in monocytes and macrophages by tamoxifen injection.

Reciprocal Regulation of mTORC1 Signaling and Ribosomal Biosynthesis Determines Cell Cycle Progression in Activated T Cells

[Science Signaling] Researchers investigated how rRibosomal biosynthesis in nucleoli was regulated in activated T lymphocytes by T cell receptor signals and the multiprotein complexes mTORC1 and mTORC2, both of which contained the kinase mTOR.

Evolutionary Dynamics of Pro-Inflammatory Caspases in Primates and Rodents

[Molecular Biology and Evolution] Investigators characterized the evolutionary history of caspase-1 and its close relatives across 19 primates and 21 rodents, focusing on differences that may cause discrepancies between humans and animal studies.

Phillyrin Inhibits Oxidative Stress and Neutrophil Extracellular Trap Formation through the KEAP1/NRF2 Pathway in Gouty Arthritis

[Immunologic Research] The authors investigated the therapeutic potential of phillyrin in gouty arthritis (GA) and explored its mechanisms of action. GA was induced in mice via intraarticular monosodium urate injection, and joint inflammation, inflammatory cell infiltration, and their level in serum/tissue were assessed.

Targeting the TNF and TNFR Superfamilies in Autoimmune Disease and Cancer

[Nature Reviews Drug Discovery] Scientists assess TNF superfamily-targeted biologics currently in clinical development for immune system-related diseases, highlighting ongoing challenges and future directions.

MAIT Cells: Conserved Watchers on the Wall

[Journal of Experimental Medicine] The authors discuss recent findings regarding the origin and regulation of mucosal-associated invariant T (MAIT) ligands and the role of MAIT cells in barrier tissues.

Phosphatidylserine Phospholipase A1 Enables GPR34-Dependent Immune Cell Accumulation in the Peritoneal Cavity

[Journal of Experimental Medicine] Researchers tested the impact of a GPR34 knock-in allele in the B-lineage. They reported that GPR34 KI promoted the peritoneal cavity accumulation of plasma cells and memory B cells.

DNA-PK Inhibition Enhances Neoantigen Diversity and Increases T Cell Responses to Immunoresistant Tumors

[Journal of Clinical Investigation] Scientists identified DNA-PK inhibitor NU7441 as a promising immunomodulator that reduced immunosuppressive proteins while increasing MHC-I expression in a panel of human melanoma cell lines.

AMBRA1 Controls the Translation of Immune-Specific Genes in T Lymphocytes

[Proceedings of The National Academy of Sciences of The United States of America] Using a whole-genome CRISPR screen for regulators of CD95-mediated T cell death, the authors identified AMBRA1, a protein previously studied for its roles in autophagy, E3 ubiquitin ligase activity, and cyclin regulation.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.

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