Immune Regulation News
Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.
PILRα on Tumor Cells Interacts with the T Cell Surface Protein CD99 to Suppress Antitumor Immunity
Investigators identified the tumor cell-expressed paired immunoglobulin-like type 2 receptor alpha (PILRα) as an immune suppressor targeting T cells using high-throughput screening.
[Nature Cancer]
Abstract
CD206+IL-4Rα+ Macrophages Are Drivers of Adverse Cardiac Remodeling in Ischemic Cardiomyopathy
[Circulation] Scientists examined whether CD206+ macrophages expressing interleukin (IL)–4Rα are key drivers of adverse left ventricular remodeling in heart failure.
Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
[Cancer Discovery] Single-cell profiling revealed responders had higher baseline intratumoral CD8+ T cells with a tumor-reactive, tissue-resident memory phenotype and a treatment-related decrease in effector regulatory T cells.
Harnessing Kupffer Cell Metabolic Rewiring: Rapamycin–Gliadin Nanoparticle as a Pivotal Strategy for Immune Tolerance in Celiac Disease
[ACS Nano ] In vivo analyses demonstrated the efficient uptake of PLN-GR by antigen-presenting cells, particularly Kupffer cells and splenic dendritic cells, driving their tolerogenic phenotypic transformation.
Microglia and CD8+ T Cell Activation Precede Neuronal Loss in a Murine Model of Spastic Paraplegia 15
[Journal of Experimental Medicine] Scientists conducted comprehensive profiling of innate and adaptive immune cells in a murine model of spastic paraplegia 15 (SPG15), a complicated form of hereditary spastic paraplegia.
Impaired Aire-Dependent IFN Signaling in the Thymus Precedes the Protective Autoantibodies to IFNα
[Journal of Experimental Medicine] Unlike mice, Aire-deficient rats develop robust autoantibodies to IFNα. Using this rat model, scientists showed that Aire regulates the thymic expression of interferon-stimulated genes, which occurs before developing anti-IFNα autoantibodies.
Amplification of Extrachromosomal MYC Paralogs Shapes Immunosuppressive Tumor Microenvironment in Small Cell Lung Cancer
[Clinical Cancer Research] Researchers investigated whether ecDNA-mediated MYC-paralogs amplification represents immunosuppressive features in small cell lung cancer.
Selective BCL-2 Inhibitor Triggers STING-Dependent Antitumor Immunity via Inducing mtDNA Release
[Journal For Immunotherapy of Cancer] Investigators found that ABT-199 activated the STING pathway to enhance the immunotherapeutic effect, and provided a ready-to-use small molecule drug for STING signaling activation.
Therapeutic Application of Regulatory T Cell in Osteoarthritis
[Journal of Microbiology Immunology and Infection] The authors summarize the recent development in using Tregs in immunotherapy, and the potential of using Tregs in osteoarthritis.
Clasp Therapeutics Doses First Patient in Phase 1 Clinical Trial With a First-in-Class T-Cell Engager Designed to Target Cancer Cells With Absolute Specificity
[Clasp Therapeutics] Clasp Therapeutics announced dosing of the initial patient in the GUARDIAN-101 Phase I trial of CLSP-1025, the first tumor-specific T cell engagers to enter clinical development.
Deconvoluting TCR-Dependent and -Independent Activation Is Vital for Reliable Ag-Specific CD4+ T Cell Characterization by AIM Assay
[Science Advances] Researchers showed that CD39+ regulatory T cell (Treg)–like and CD26hi TH22–like cells undergo T cell receptor–independent activation by cytokines during antigen stimulation, leading to nonspecific up-regulation of activation-induced marker readouts.
Regulatory T Cell Memory: Implications for Malaria
[The Journal of Immunology] The authors explore the biology of Treg memory, with a focus on malaria, and examine the immunological implications of maintaining a suppressive mTreg population in malaria immunity.
For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.
