Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
mTOR Controls Ependymal Cell Differentiation by Targeting the Alternative Cell Cycle and Centrosomal Proteins
[EMBO Reports] Investigators demonstrated that mTORC1 inhibition by rapamycin preserves the progenitor pool by reinforcing quiescence and preventing alternative cell cycle progression for centriole amplification.
APOE Deficiency Inhibits Amyloid-Facilitated (A) Tau Pathology (T) and Neurodegeneration (N), Halting Progressive ATN Pathology in a Preclinical Model
[Molecular Psychiatry] Scientists studied the role of APOE in a preclinical model that robustly mimics amyloid-facilitated tau pathology and subsequent neurodegeneration generated by crossing 5xFAD and TauP301S mice.
Regional Differences in Progenitor Metabolism Shape Brain Growth during Development
[Cell] Investigators provided a single-cell-resolution birthdate atlas of the mouse brain, which reveals that while hindbrain neurogenesis is transient and restricted to early development, forebrain neurogenesis is temporally sustained through reduced consumptive divisions of ventricular zone progenitors.
Neural-Activity-Regulated and Glia-Mediated Control of Brain Lymphatic Development
[Cell] Researchers reported that the brain controls the development of mural lymphatic endothelial cells via a specialized glial subpopulation, slc6a11b+ radial astrocytes, a process modulated by neural activity in zebrafish.
CLU Alleviates Alzheimer’s Disease-Relevant Processes by Modulating Astrocyte Reactivity and Microglia-Dependent Synaptic Density
[Neuron] Through unbiased proteomic profiling and functional validation in clusterin (CLU)-deficient astrocytes, scientists identified increased nuclear factor κB-dependent signaling and complement C3 secretion.
NEUROD1 Efficiently Converts Peripheral Blood Cells into Neurons with Partial Reprogramming by Pluripotency Factors
[Proceedings of The National Academy of Sciences of The United States of America] Investigators reported a procedure for converting peripheral blood cells into functional neurons. Their method utilized partial reprogramming strategies with Yamanaka reprogramming factors and the neuronal bHLH NEUROD1 to overcome epigenetic barriers.
Parallel Processing of past and Future Memories through Reactivation and Synaptic Plasticity Mechanisms during Sleep
[Nature Communications] Scientists showed that in male mice, hippocampal CA1 neurons showed an organized synchronous activity in prelearning home cage sleep that correlated with the learning ensembles only in engram cells, termed preconfigured ensembles.
Lysosomal TPC2 Channels Disrupt Ca2+ Entry and Dopaminergic Function in Models of LRRK2-Parkinson’s Disease
[Journal of Cell Biology] Investigators identified novel crosstalk between depolarization-induced entry of Ca2+ and lysosomal cation release in maintaining dopaminergic neuronal function.
Transcriptional Regulation by PHGDH Drives Amyloid Pathology in Alzheimer’S Disease
[Cell] Researchers showed that altered expression of the late-onset Alzheimer's disease (AD) biomarker phosphoglycerate dehydrogenase (PHGDH) modulates AD pathology in mice and human brain organoids independent of its enzymatic activity.
Loss of Intracellular ATP Affects Axoplasmic Viscosity and Pathological Protein Aggregation in Mammalian Neurons
[Science Advances] The authors showed that intracellular adenosine triphosphate (ATP) regulated axoplasmic viscosity and protein aggregation in mammalian neurons.
Synaptophysin Accelerates Synaptic Vesicle Fusion by Expanding the Membrane upon Neurotransmitter Loading
[Science Advances] Researchers showed that during transmitter loading, synaptic vesicles substantially increased in size, which was reversible and required synaptophysin, an abundant membrane protein with an unclear function.
Progranulin Deficiency in the Brain: The Interplay between Neuronal and Non-Neuronal Cells
[Translational Neurodegeneration] The authors highlight the broad spectrum of clinical phenotypes associated with progranulin deficiency, including primary progressive aphasia and behavioral variant of frontotemporal dementia.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
