Interleukin-6 Neutralizing Antibody Attenuates the Hypersecretion of Airway Mucus via Inducing the Nuclear Translocation of Nrf2 in Chronic Obstructive Pulmonary Disease

To investigate the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated, human organoid model of trachea was established and all treated with IL-6 and/or IL-6 Ab.