NewslettersNeural Cell News Calpain-Mediated Cleavage Generates a ZBTB18 N-Terminal Product That Regulates HIF1A Signaling and Glioblastoma Metabolism By lbeveridge - June 17, 2022 0 Investigators reported that in glioblastoma, the tumor suppressor ZBTB18 is targeted for protein cleavage by the intracellular protease calpain. [iScience] AbstractGraphical Abstract