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lbeveridge

Aging-Regulated PNUTS Maintains Endothelial Barrier Function via SEMA3B Suppression

[Communications Biology] Investigators determined the role of Phosphatase 1 Nuclear Targeting Subunit (PNUTS) in endothelial cell aging. They confirmed that PNUTS was repressed in senescent endothelial cells.

Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings from a Randomized Controlled Study

[Journal Of The American Heart Association] The authors examined the acute effects of provoked anger, and secondarily, anxiety and sadness on endothelial cell health.

New $2 Million Research Initiative Will Study Heart and Brain Health in People With Autism

[American Heart Association] According to the US Centers for Disease Control and Prevention, 1 in 36 children and 1 in 45 adults in the US have autism, a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech and nonverbal communication.

BTK Drives Neutrophil Activation for Sterilizing Antifungal Immunity

[Journal Of Clinical Investigation] Upon fungal exposure, BTK was activated in human neutrophils in a TLR2-, Dectin-1-, and FcγR-dependent manner, triggering the oxidative burst.

Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics

[Ophthalmology] Researchers investigated the effect of seasonal-driven environmental factors on the density, morphology, and dynamic behavior of human corneal immune cell subsets.

Pan-Cancer Analysis of Prognostic and Immunological Role of IL4I1 in Human Tumors: A Bulk Omics Research and Single Cell Sequencing Validation

[Discover Oncology] IL4I1 was significantly overexpressed in the majority of tumors, and the imbalance of IL4I1 was significantly correlated with overall survival and pathological stage. Moreover, total IL4I1 protein was increased in cancer.

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CRKL but Not CRKII Contributes to Hemin-Induced Erythroid Differentiation of CML

[Journal of Cellular and Molecular Medicine] miR-429-CT10 regulation of kinase-like (CRKL) upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leemia (CML) patient and CR patient samples.

Myospreader Improves Gene Editing in Skeletal Muscle by Myonuclear Propagation

[Proceedings Of The National Academy Of Sciences Of The United States Of America] By screening nuclear localization signals and nuclear export signals, researchers identified “Myospreader,” a combination of short peptide sequences that promoted myonuclear propagation.

FLT3L Governs the Development of Partially Overlapping Hematopoietic Lineages in Humans and Mice

[Cell] The authors described three humans homozygous for a loss-of-function FMS-related tyrosine kinase 3 ligand (FLT3L) G variant with a history of various recurrent infections, including severe cutaneous warts.