lbeveridge

[Circulation Research] Investigators used mouse models of DOCA+salt treatment and adoptive transfer of CD8+ T cells (CD8T) from hypertensive animals to normotensive animals in in vivo studies.

[Nature Immunology] The authors found that regulatory T cell with an effector phenotype (eTreg) cell expression of PD-1 acted as a sensor to rapidly tune the pool of eTreg cells at homeostasis and during inflammatory processes.

[Nature Immunology] Scientists showed that LAG3 moved to the immunological synapse and associated with the T cell receptor (TCR)-CD3 complex in CD4+ and CD8+ T cells, in the absence of binding to major histocompatibility complex class II — its canonical ligand.

[Cell Death & Differentiation] Researchers demonstrated the importance of the ABIN1 UBD domain, which mediated the ABIN1-A20 axis, at limiting RIPK1 activation-dependent cell death during embryonic development.

[Science Immunology] The authors contextualized macrophage heterogeneity across mouse tissues and inflammatory conditions, specifically aiming to define a common framework of macrophage activation.

[Science Immunology] Investigators established a role for CD8+ T cell-dependent anti-tumor immunity in mediating sex differences in tumor aggressiveness, which was driven by the gonadal androgen but not sex chromosomes.