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lbeveridge

Deformable Smart DNA Nanomachine for Synergistic Intracellular Cancer-Related miRNAs Imaging and Chemo-Gene Therapy of Drug-Resistant Tumors

[Small] Deformable smart DNA nanomachines were developed for synergistic intracellular cancer-related miRNAs imaging and chemo-gene therapy of drug-resistant tumors.

An International Learning Collaborative Phase II Trial for Haploidentical Bone Marrow Transplant in Sickle Cell Disease

[Blood] Investigator conducted an international multicenter Phase II clinical trial testing the hypothesis that non-myeloablative related haploidentical BMT with thiotepa and post-transplant cyclophosphamide will result in two-year event-free survival of at least 80%.

PTCy Versus ATG as Graft-Versus-Host Disease Prophylaxis in Mismatched Unrelated Stem Cell Transplantation

[Blood Cancer Journal] Investigators analyzed the outcome of rabbit anti-thymocyte globulin vs. post-transplantation cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood allogeneic stem cell transplantations from mismatched unrelated donors between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation.

A Humanized Mouse Model for Adeno-Associated Viral Gene Therapy

[Nature Communications] The authors describe a human liver chimeric transgene-free Il2rg−/−/Rag2−/−/Fah−/−/Aavr−/− (TIRFA) mouse model overcoming this translational roadblock, by combining liver humanization with AAV receptor (AAVR) ablation, rendering murine cells impermissive to AAV transduction.

Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

[Advanced Science] Researchers presented a scaffold that facilitated the localized administration of the transforming growth factor β gene in the proximal region to accelerate nerve regeneration, while simultaneously delivering nicotinamide mononucleotide adenylyltransferase 2 to the distal region to mitigate Wallerian degeneration.

[18F]FDG PET/CT for Prognosis and Toxicity Prediction of Diffuse Large B Cell Lymphoma Patients With Chimeric Antigen Receptor T Cell Therapy

[European Journal Of Nuclear Medicine And Molecular Imaging] The authors evaluated the value of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) combining with clinical indices and laboratory indicators in predicting outcomes and toxicity of anti-CD19 CAR T-cell therapy for diffuse large B-cell lymphoma patients.

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Autophagy Regulates the Maturation of Hematopoietic Precursors in the Embryo

[Nature Communications] Using combined approaches, including scRNA-seq, researchers confirmed that autophagy-related gene 5 deletion interrupted developmental temporal order of endothelial to hematopoietic transition to further affect the pre-HSC I maturation.

Malignant Progression of Pre-Leukemic Disorders

[Blood] Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.

Alterations in Exocrine Pancreatic Function after Acute Pancreatitis

[Pancreatology] Investigators discuss the epidemiology, pathophysiology, and clinical management of exocrine pancreatic dysfunction after acute pancreatitis while highlighting key knowledge gaps.