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Immune Regulation News
Thymol Improves Ischemic Brain Injury by Inhibiting Microglia-Mediated Neuroinflammation
[Brain Research Bulletin] The authors found that thymol treatment could ameliorate post-stroke neurological impairment and reduce infarct volume by mitigating microglial activation and pro-inflammatory response.
Immune Regulation News
T Cell Exhaustion and Senescence for Ovarian Cancer Immunotherapy
[Seminars In Cancer Biology] The authors summarize the phenotypic and functional features of exhaust and senescent T cells, and describes the key drivers of the two T cell dysfunctional states in the tumor microenvironment and their functional roles in ovarian cancer.
Extracellular Matrix News
In Vivo Monitoring of Active Subretinal Fibrosis in Mice Using Collagen Hybridizing Peptides
[Lab Animal] Using two mouse models, researchers imaged active fibrotic lesions using fluorescently labeled collagen hybridizing peptides, short peptides that bind to single α-chain collagen structures during collagen remodeling.
Immune Regulation News
Mechanisms Underlying the Direct Programming of Mouse Embryonic Fibroblasts to Thymic Epithelial Cells by FOXN1
[Development] Researchers characterized fibroblasts transdifferentiated into thymic epithelial cell-like cells programming at the cellular and molecular level in mouse to determine how it proceeded, and have identified mechanisms that can be targeted for improving this process.
Immune Regulation News
Vγ9Vδ2 T Cells Recognize Butyrophilin 2A1 and 3A1 Heteromers
[Nature Immunology] The crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engaged the side of the γδTCR, leaving the apical TCR surface bioavailable.
Immune Regulation News
The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues
[Journal of Neuro-Oncology] Scientists performed a series of in vitro experiments using canine Tregs and patient-derived canine glioma cell lines to interrogate the CCL2-CCR4 signaling axis in the canine.
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PARP11 Inhibition Inactivates Tumor-Infiltrating Regulatory T Cells and Improves the Efficacy of Immunotherapies
[Cell Reports Medicine] Scientists demonstrated that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of tumor-infiltrating regulatory T cells.
PD-1/LAG-3 Co-Signaling Profiling Uncovers CBL Ubiquitin Ligases as Key Immunotherapy Targets
[EMBO Molecular Medicine] To identify shared features associated to PD-1/LAG-3 dysfunctionality in human cancers and T cells, multiomic expression profiles were obtained for all TCGA cancers immune infiltrates.
Mucosal Signatures of Pathogenic T Cells in HLA-B*27+ Anterior Uveitis and Axial Spondyloarthritis
[JCI Insight] Investigators identified a bacterial peptide that could be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU.