[Experimental Cell Research] YAP1 expression and autophagy constituted positive feedback, in which YAP1 inhibition decreased the autophagy activity in liver tumor cells by hepatocyte-specific Yap1 knockout mice.
[Cellular Signalling] Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.
[Oncology Reports] Scientists discuss the relationship of protein tyrosine phosphatases (PTPs) with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.
[Biomaterials] Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.
[Medical Science Monitor] RNA-seq data from the Genotype-Tissue Expression Project and TCGA were analyzed in combination. In vitro cellular and molecular studies were conducted using SK-Hep-1 and Hep3B cells.
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.