lbeveridge

[Proceedings of The National Academy of Sciences of The United States of America] Investigators reported significant transcriptomic signatures of Cas13bt3 expression in retinal cells and show all-in-one adeno-associated virus gene therapy with Cas13bt3 can effectively silence VEGFA mRNA in human retinal organoids and humanized VEGF transgenic mouse models.

[Pharmacy Times] The FDA granted an accelerated approval to asciminib for adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase.

[Nature Immunology] Investigators showed that mice harboring the corresponding Bcl11bN440K mutation show the emergence of natural killer/group 1 innate lymphoid cell-like NKp46+ cells in the thymus and reduction in TBR1+ neurons in the neocortex, which were observed with loss of Bcl11a but not Bcl11b.

[Nature Communications] Scientists reported a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of CSCs enriched tumors.

Investigators combined multicolor lineage tracing with chemical mutagenesis in mice to show that a large proportion of intestinal tumours have a multiancestral origin. Polyclonal tumors retained a structure comprising subclones with...

Crosstalk between vascular endothelial cells and fibroblasts in Idiopathic Pulmonary Fibrosis mediated by bone morphogenic protein signalling may be important for remodeling of the lung. A novel modality for monitoring...