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YAP1 Suppression Inhibits Autophagy and Improves the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma

[Experimental Cell Research] YAP1 expression and autophagy constituted positive feedback, in which YAP1 inhibition decreased the autophagy activity in liver tumor cells by hepatocyte-specific Yap1 knockout mice.

EGFR and Lyn Inhibition Augments Regorafenib Induced Cell Death in Sorafenib Resistant 3D Tumor Spheroid Model

[Cellular Signalling] Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.

Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma Progression

[Oncology Reports] Scientists discuss the relationship of protein tyrosine phosphatases (PTPs) with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.

The Transcription Factor ATF3 Switches Cell Death from Apoptosis to Necroptosis in Hepatic Steatosis in Male Mice

[Nature Communications] The authors show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death.

Tuning the Corona-Core Ratio of Polyplex Micelles for Selective Oligonucleotide Delivery to Hepatocytes or Hepatic Immune Cells

[Biomaterials] Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.

NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma

[Medical Science Monitor] RNA-seq data from the Genotype-Tissue Expression Project and TCGA were analyzed in combination. In vitro cellular and molecular studies were conducted using SK-Hep-1 and Hep3B cells.


Immunoproteasome Inhibition Prevents Progression of Castration-Resistant Prostate Cancer

[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.

Plasma Extracellular Vesicle circRNA Signature and Resistance to Abiraterone in Metastatic Castration-Resistant Prostate Cancer

[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.

WNT Pathway Mutations in Metachronous Oligometastatic Castration-Sensitive Prostate Cancer

[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.