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lbeveridge

Optimizing Mesenchymal Stem Cell Extracellular Vesicles for Chronic Wound Healing: Bioengineering, Standardization, and Safety

[Regenerative Therapy] MSC-derived extracellular vesicles offer an innovative regenerative medicine approach, delivering stem cell-derived therapeutic cargo in engineered nanoscale delivery systems.

Gene Regulatory Network Topology Governs Resistance and Treatment Escape in Glioma Stem-Like Cells

[Science Advances] Through inference of transcriptional regulatory networks of patient-derived glioma stem cells (PD-GSCs) at single-cell resolution, researchers demonstrated how the topology of transcription factor interaction networks drove distinct trajectories of cell-state transitions in PD-GSCs resistant or susceptible to cytotoxic drug treatment.

Strategies for the Isolation and Identification of Gastric Cancer Stem Cells

[Stem Cells International] Investigators discuss the surface biomarkers, isolation techniques, and identification methods of gastric cancer stem cells, as well as their role in the treatment of gastric cancer.

SETD3 Is a Mechanosensitive Enzyme That Methylates Actin on His-73 to Regulate Mitochondrial Dynamics and Function

[Journal of Cell Science] Scientists showed that SET domain protein 3 (SETD3), a recently described actin histidine methyltransferase, directly methylates actin Histidine-73 and enhances F-actin polymerization on mitochondria.

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

[Cancer Research] Using the Hi-MYC prostate cancer mouse model, the authors demonstrated that an obesogenic high-fat diet rich in saturated fats accelerates the development of c-MYC–driven invasive prostate cancer through metabolic rewiring.

The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain

[Advanced Science] Magnetic resonance elastography studies have shown that abnormal processes such as neuronal degeneration, demyelination, inflammation, and vascular leakage lead to tissue softening. In contrast, neuronal proliferation, cellular network formation, and higher vascular pressure result in brain stiffening.

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Characterization of Perivascular Alveolar Epithelial Stem Cells and Their Niche in Lung Homeostasis and Cancer

[Stem Cell Reports] Scientists reported a CD44high subpopulation of alveolar type II stem cells characterized by increased expression of genes that regulated immune signaling even during steady-state homeostasis.

Environmental Pollutants Exposure-Derived Extracellular Vesicles: Crucial Players in Respiratory Disorders

[Thorax] PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders, and extracellular vesicles.

Current State of Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis

[Respiratory Research] The authors review the existing literature on the signaling pathways linked to the pathogenesis of idiopathic pulmonary fibrosis , both within national and international contexts.