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lbeveridge

Thymol Improves Ischemic Brain Injury by Inhibiting Microglia-Mediated Neuroinflammation

[Brain Research Bulletin] The authors found that thymol treatment could ameliorate post-stroke neurological impairment and reduce infarct volume by mitigating microglial activation and pro-inflammatory response.

T Cell Exhaustion and Senescence for Ovarian Cancer Immunotherapy

[Seminars In Cancer Biology] The authors summarize the phenotypic and functional features of exhaust and senescent T cells, and describes the key drivers of the two T cell dysfunctional states in the tumor microenvironment and their functional roles in ovarian cancer.

In Vivo Monitoring of Active Subretinal Fibrosis in Mice Using Collagen Hybridizing Peptides

[Lab Animal] Using two mouse models, researchers imaged active fibrotic lesions using fluorescently labeled collagen hybridizing peptides, short peptides that bind to single α-chain collagen structures during collagen remodeling.

Mechanisms Underlying the Direct Programming of Mouse Embryonic Fibroblasts to Thymic Epithelial Cells by FOXN1

[Development] Researchers characterized fibroblasts transdifferentiated into thymic epithelial cell-like cells programming at the cellular and molecular level in mouse to determine how it proceeded, and have identified mechanisms that can be targeted for improving this process.

Vγ9Vδ2 T Cells Recognize Butyrophilin 2A1 and 3A1 Heteromers

[Nature Immunology] The crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engaged the side of the γδTCR, leaving the apical TCR surface bioavailable.

The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues

[Journal of Neuro-Oncology] Scientists performed a series of in vitro experiments using canine Tregs and patient-derived canine glioma cell lines to interrogate the CCL2-CCR4 signaling axis in the canine.

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PARP11 Inhibition Inactivates Tumor-Infiltrating Regulatory T Cells and Improves the Efficacy of Immunotherapies

[Cell Reports Medicine] Scientists demonstrated that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of tumor-infiltrating regulatory T cells.

PD-1/LAG-3 Co-Signaling Profiling Uncovers CBL Ubiquitin Ligases as Key Immunotherapy Targets

[EMBO Molecular Medicine] To identify shared features associated to PD-1/LAG-3 dysfunctionality in human cancers and T cells, multiomic expression profiles were obtained for all TCGA cancers immune infiltrates.

Mucosal Signatures of Pathogenic T Cells in HLA-B*27+ Anterior Uveitis and Axial Spondyloarthritis

[JCI Insight] Investigators identified a bacterial peptide that could be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU.