CFTR Reduces the Proliferation of Lung Adenocarcinoma and Is a Strong Predictor of Survival in Both Smokers and Non-Smokers

Scientists systematically analyzed expression signatures of all 48 human ABC transporters in samples from 8562 patients across 14 different cancer types. The association between CFTR (ABCC7) expression and outcomes was analyzed experimentally using knock-downs and pharmacological CFTR stimulation.