Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids

Investigators found that overexpression of farnesoid X receptor (FXR), a main receptor for bile acids, improved the retention and cardioprotection of adipose tissue-derived MSC administered by intramyocardial injection in mice with myocardial infarction.