NewslettersESC & iPSC News Acute Deletion of TET Enzymes Results in Aneuploidy in Mouse Embryonic Stem Cells through Decreased Expression of Khdc3 By Noshin Noorjahan - October 26, 2022 0 Investigators showed that acute deletion of all three Tet genes, after brief exposure of triple-floxed, Cre-ERT2-expressing mESCs to 4-hydroxytamoxifen, resulted in chromosome mis-segregation and aneuploidy. [Nature Communications] Full Article