Noshin Noorjahan

[Cell Metabolism] Researchers demonstrated that cytochrome b (CYTB) also encoded an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code.

[Journal of Cell Biology] Investigators revealed the mechanism of heterochromatin targeting of histone H3 lysine36 dimethylation (H3K36me2). Among several H3K36 methyltransferases, NSD2 was responsible for inducing heterochromatic H3K36me2.

[Stem Cell Reports] Scientists investigated the role of zinc finger ZZ-type containing 3 (ZZZ3) in human ESCs homeostasis. They found that knockdown of ZZZ3 negatively impacted ribosome biogenesis, translation, and mTOR signaling, leading to a significant reduction in cell proliferation.

[NAR Genomics and Bioinformatics] Researchers performed a nuclear knockdown of Malat1 in mESCs, causing the de-regulation of 320 genes and aberrant splicing of 90 transcripts, some of which potentially affecting the translated protein sequence.

[Trends in Cell Biology] Investigators provide a comprehensive assessment of published forward programming protocols that are based on forced expression of key lineage transcription factors.

[MIT Technology Review] The experiment, at the University of Florida, is an attempt to create a large animal starting only from stem cells—no egg, no sperm, and no conception.