Unraveling the Impact of ZZZ3 on the mTOR/Ribosome Pathway in Human Embryonic Stem Cells Homeostasis

Scientists investigated the role of zinc finger ZZ-type containing 3 (ZZZ3) in human ESCs homeostasis. They found that knockdown of ZZZ3 negatively impacted ribosome biogenesis, translation, and mTOR signaling, leading to a significant reduction in cell proliferation.