Noshin Noorjahan

[Diabetes] Scientists generated a humanized mouse model expressing endothelial-specific human cell death-inducing DNA fragmentation factor-α-like effector C (E-CIDECtg). E-CIDECtg mice exhibited protection against high-fat diet-impaired glucose intolerance, insulin resistance, and dyslipidemia.

[American Journal of Respiratory Cell and Molecular Biology] Differential expression, gene set enrichment, cell-cell communication, and trajectory reconstruction analyses were performed on lung endothelial cells from single-cell RNA-seq of Sugen-hypoxia, monocrotaline, and control rats.

[American Journal of Respiratory Cell and Molecular Biology] Researchers described the contribution of two intracellular chloride channel proteins CLIC1 and CLIC4, both highly expressed in pulmonary arterial hypertension (PAH) and cancer, to mitochondrial dysfunction and energy metabolism in PAH endothelium.

[International Journal of Biological Macromolecules] The authors showed that in endothelial cells the plasma membrane receptor CD93 was structured as a dimer and that this oligomeric form was physiologically instrumental for the binding of CD93 to its ligand Multimerin-2.

[European Journal of Pharmaceutics and Biopharmaceutics] Investigators formulated and studied the physicochemical characteristics of ATP-loaded lipidoid nanoparticles using the C12-200 ionizable cationic lipid and other helper lipids.

[iScience] In studies testing the role of boysenberry polyphenols (BoyP) in brown adipose tissue (BAT), researchers found that BoyP decreased endothelial cell apoptosis, enhanced capillarization in BAT, and ameliorated dietary BAT dysfunction.