ISWI Chromatin Remodeling Complexes Recruit NSD2 and H3K36me2 in Pericentromeric Heterochromatin

Investigators revealed the mechanism of heterochromatin targeting of histone H3 lysine36 dimethylation (H3K36me2). Among several H3K36 methyltransferases, NSD2 was responsible for inducing heterochromatic H3K36me2.