NewslettersDermal Cell News CDK12 Is Hyperactivated and a Synthetic-Lethal Target in BRAF-Mutated Melanoma By Laurisa Dohm - October 31, 2022 0 Scientists found that melanoma cells harbored constitutively high CDK12 activity, and that its inhibition decreased the expression of long genes containing multiple exons, including many genes involved in DNA repair. [Nature Communications] Full Article