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Laurisa Dohm
Dermal Cell News
Green Cocoon-Derived Sericin Reduces Cellular Damage Caused by Radiation in Human Keratinocytes
[Scientific Reports] Researchers investigated the effects of green cocoon-derived sericin on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction.
Dermal Cell News
Collagen I Protects Human Keratinocytes HaCaT against UVB Injury via Restoring PINK1/Parkin-Mediated Mitophagy
[Archives Of Biochemistry And Biophysics] Cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis.
Dermal Cell News
ANKRD1 Is a Mesenchymal-Specific Driver of Cancer-Associated Fibroblast Activation Bridging Androgen Receptor Loss to AP-1 Activation
[Nature Communications] Investigators identified ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct androgen receptor negative control in human dermal fibroblasts and a key driver of cancer-associated fibroblasts conversion, independent of cellular senescence.
Dermal Cell News
Saracatinib Inhibits Necroptosis and Ameliorates Psoriatic Inflammation by Targeting MLKL
[Cell Death & Disease] In an imiquimod-induced psoriasis mouse model, saracatinib effectively blocked mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory responses in vivo.
Dermal Cell News
Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation
[JCI Insight] Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion.
Dermal Cell News
Nuclear Mechanotransduction on Skin Stem Cell Fate Regulation
[Current Opinion In Cell Biology] Scientists focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance.
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Targeting EMT Using Low-Dose Teniposide by Downregulating ZEB2-Driven Activation of RNA Polymerase I in Breast Cancer
[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.
A Prismatic View of the Epigenetic-Metabolic Regulatory Axis in Breast Cancer Therapy Resistance
[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.
SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes
[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.