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Laurisa Dohm

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

[Nano Letters] The authors highlight the current state of the art in nanozyme-engineered hydrogels for anti-inflammatory and skin regeneration applications.

Adipose-Derived Stem Cells in Immune-Related Skin Disease: A Review of Current Research and Underlying Mechanisms

[Stem Cell Research & Therapy] The authors review the mechanisms underlying the immunomodulatory effects of adipose-derived stem cells, as well as progress in research on immune-related skin diseases.

Activating Autophagy Promotes Skin Regeneration Induced by Mechanical Stretch during Tissue Expansion

[Burns & Trauma] Activating autophagy accelerated skin regeneration during tissue expansion by enhancing the proliferation of cells and the number of epidermal basal and hair follicle stem cells, reducing apoptosis, improving angiogenesis, and promoting collagen synthesis and growth factor secretion.

Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation

[Nature Communications] Global phosphoproteomic and fucoproteomic profiling, coupled with in vitro and in vivo functional validation, further revealed that anfrogen receptor-induced FUT4 fucosylates L1 cell adhesion molecule, which was required for FUT4-increased metastatic capacity.

Development of Tight Junction-Strengthening Compounds Using a High-Throughput Screening System to Evaluate Cell Surface-Localized Claudin-1 in Keratinocytes

[Scientific Reports] To obtain compounds that can improve tight junction function, scientists developed a novel high-throughput screening system termed live-cell immunostaining to evaluate cell surface-localized claudin-1 with high selectivity using normal human epidermal keratinocytes.

Utility of Allogeneic Stem Cell Transplantation for Adult Ph+ALL eith Complete Molecular Remission

[American Journal Of Hematology] Researchers compared the outcomes between Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) patients who did or did not undergo allogeneic stem cell transplantation in the first complete remission.

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CAR Affinity Modulates the Sensitivity of CAR-T Cells to PD-1/PD-L1-Mediated Inhibition

[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.