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Laurisa Dohm

Green Cocoon-Derived Sericin Reduces Cellular Damage Caused by Radiation in Human Keratinocytes

[Scientific Reports] Researchers investigated the effects of green cocoon-derived sericin on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction.

Collagen I Protects Human Keratinocytes HaCaT against UVB Injury via Restoring PINK1/Parkin-Mediated Mitophagy

[Archives Of Biochemistry And Biophysics] Cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis.

ANKRD1 Is a Mesenchymal-Specific Driver of Cancer-Associated Fibroblast Activation Bridging Androgen Receptor Loss to AP-1 Activation

[Nature Communications] Investigators identified ANKRD1 as a mesenchymal-specific transcriptional coregulator under direct androgen receptor negative control in human dermal fibroblasts and a key driver of cancer-associated fibroblasts conversion, independent of cellular senescence.

Saracatinib Inhibits Necroptosis and Ameliorates Psoriatic Inflammation by Targeting MLKL

[Cell Death & Disease] In an imiquimod-induced psoriasis mouse model, saracatinib effectively blocked mixed lineage kinase domain-like protein (MLKL) phosphorylation and inflammatory responses in vivo.

Differential Histone Acetylation and Super-Enhancer Regulation Underlie Melanoma Cell Dedifferentiation

[JCI Insight] Scientists identified ITGA3 gene as marked by a super-enhancer element in the Epgn3 invasive cells. Silencing of ITGA3 enhanced invasiveness in both in vitro and in vivo systems suggesting it as a negative regulator of invasion.

Nuclear Mechanotransduction on Skin Stem Cell Fate Regulation

[Current Opinion In Cell Biology] Scientists focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance.


Clinical Implications of Wnt Pathway Genetic Alterations in Men with Advanced Prostate Cancer

[Prostate Cancer and Prostatic Diseases] Investigators utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort clinical-genomic database for this retrospective analysis.

Targeting Valine Catabolism to Inhibit Metabolic Reprogramming in Prostate Cancer

[Cell Death & Disease] Through the suppression of branched-chain amino acid (BCAA) availability, researchers reported significantly reduced lipid content, strongly indicating that BCAAs were important lipogenic fuels in prostate cancer.

Embryonic Microenvironment Suppresses YY1 and YY1-Related Genes in Prostate Cancer Stem Cells

[Pathology - Research and Practice] To investigate the embryonic microenvironment impact on Yin yang 1 (YY1) expression in CSC populations, firstly cancer stem cells (CSCs) were microinjected into the inner cell mass of blastocysts and then prostate CSCs were co-cultured with blastocysts.