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Laurisa Dohm

Psoriatic Dermal-Derived Mesenchymal Stem Cells Induced C3 Expression in Keratinocytes

[Clinical, Cosmetic and Investigational Dermatology] Investigators analyzed the C3 and its upstream S100A9, S100A8 and downstream MCP1 in psoriatic and control skin, and in normal human epidermal keratinocytes co-cultured with psoriatic versus control dermal-derived mesenchymal stem cells by mRNA, isobaric tags for relative and absolute quantitative, and simple Western analysis.

Thy1 Marks a Distinct Population of Slow-Cycling Stem Cells in the Mouse Epidermis

[Nature Communications] Multicolor lineage tracing analyses and mathematical modeling revealed that Thy1+ basal keratinocytes did not compete neutrally alike interfollicular progenitors and contributed long-term to both epidermal replenishment and wound repair.

Hotter Summers May Fuel Increase in Skin Cancers, Doctors Warn

[The Guardian] Experts have said higher summer temperatures caused by the climate crisis may fuel an increase in cases of potentially deadly skin cancers such as melanoma.

Griffith Launches Two Cancer Research Centres with $4.6M ACRF Funding

[Griffith University] Griffith University has launched two cancer research centres backed by $4.6 million in funding from the Australian Cancer Research Foundation (ACRF) this month.

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CAR Affinity Modulates the Sensitivity of CAR-T Cells to PD-1/PD-L1-Mediated Inhibition

[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.