Laurisa Dohm

Hepatic Cell News

Singapore Scientists and Physicians Awarded Prestigious NRF Grant To Develop Novel Therapies for Liver Cancer

[National Research Foundation Singapore (EurekAlert)] A team of multidisciplinary scientists has been awarded the prestigious National Research Foundation (NRF) Singapore grant to uncover the fundamental mechanisms of liver disease progression from fatty liver disease to fibrosis/cirrhosis, and eventually, liver cancer.

Dermal Cell News

The Mitochondrial RNA Polymerase POLRMT Promotes Skin Squamous Cell Carcinoma Cell Growth

[Cell Death Discovery] Using patient-derived primary skin skin squamous cell carcinoma (SCC) cells or immortalized lines, the authors demonstrated that RNA polymerase mitochondrial (POLRMT) shRNA or knockout (KO) potently suppressed mitochondrial DNA (mtDNA) transcription and suppressed cell viability, proliferation and migration.

Dermal Cell News

Silencing LINC00665 Inhibits Cutaneous Melanoma In Vitro Progression and Induces Apoptosis via the miR-339-3p/TUBB

[Journal of Clinical Laboratory Analysis] Researchers reported that silencing LINC00665 decreased cutaneous melanoma (CM) cell viability; inhibited colony formation, cell cycle progression, migration and invasion; enhanced apoptosis; and upregulated miR-339-3p.

Dermal Cell News

Rhein Promotes the Proliferation of Keratinocytes by Targeting Estrogen Receptors for Skin Ulcer Treatment

[BMC Complementary and Alternative Medicine] Researchers reported that Rhein increased the proportion of cells in the S phase of the cell cycle and promoted keratinocyte proliferation.

Dermal Cell News

Interaction of LATS1 With SMAC Links the MST2/Hippo Pathway with Apoptosis in an IAP-Dependent Manner

[Cell Death & Disease] Using mass spectrometry-based interaction proteomics, the authors identified the Second Mitochondria-derived Activator of Caspases (SMAC) as a novel LATS1 interactor.

Dermal Cell News

Wound Healing, Fibroblast Heterogeneity, and Fibrosis

[Cell Stem Cell] The authors discuss the current state of knowledge in fibroblast biology and heterogeneity, with a primary focus on the role of fibroblasts in skin wound repair.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Laurisa Dohm

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