Laurisa Dohm

Dermal Cell News

A Previously Unknown Argonaute 2 Variant Positively Modulates the Viability of Melanoma Cells

[Cellular and Molecular Life Sciences] Investigators reported that expression of Argonaut 2 (AGO2-ex1/3) provides a survival advantage for melanoma cells while the knockdown causes significantly reduced proliferation and increases apoptosis.

Dermal Cell News

δ-Catenin Requirement in Keratinocyte Proliferation and DNA Repair Identifies a Therapeutic Target for Photoaging

[Journal of Investigative Dermatology] Researchers discovered that δ-catenin is predominantly distributed in keratinocytes of the skin epidermis, and functionally accelerates cell proliferation and DNA repair.

Dermal Cell News

Role of ROS-Mediated Autophagy in Melanoma

[Molecular Medicine Reports] The authors examine the production of reactive oxygen species (ROS) and the role of oxidative stress in melanoma, and summarize the role of ROS‑mediated autophagy in melanomagenesis and melanoma cell fate decision following treatment with various anticancer drugs.

Dermal Cell News

p38 MAPK-Dependent Phosphorylation of Transcription Factor SOX2 Promotes an Adaptive Response to BRAF Inhibitors in Melanoma Cells

[Journal of Biological Chemistry] Using functional studies, the authors demonstrated that SOX2 depletion increased sensitivity of melanoma cells to BRAF kinase inhibitors (BRAFi), whereas overexpression of a phosphomimetic SOX2-S251E mutant was sufficient to drive resistance and desensitize melanoma cells to BRAFi in vitro and in a Zebrafish xenograft model.

Dermal Cell News

Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration

[Stem Cell Research & Therapy] Researchers reported that Pluronic F-127/human adipose-derived mesenchymal stem cells-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased expression of Ki67, α-SMA, and CD31, facilitated collagen synthesis, up-regulated expression of skin barrier proteins, and reduced inflammation.

Dermal Cell News

LINE-1 RNA Causes Heterochromatin Erosion and Is a Target for Amelioration of Senescent Phenotypes in Progeroid Syndromes

[Science Translational Medicine] Authors showed that LINE-1 (Long Interspersed Nuclear Element-1) RNA accumulation was an early event in both typical and atypical human progeroid syndromes.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Laurisa Dohm

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