Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation

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Global phosphoproteomic and fucoproteomic profiling, coupled with in vitro and in vivo functional validation, further revealed that anfrogen receptor-induced FUT4 fucosylates L1 cell adhesion molecule, which was required for FUT4-increased metastatic capacity.
[Nature Communications]
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