NewslettersESC & iPSC News A Congenital Hydrocephalus-Causing Mutation in Trim71 Induces Stem Cell Defects via Inhibiting Lsd1 mRNA Translation By Noshin Noorjahan - January 4, 2023 0 Using mESCs as a model, scientists revealed that the mouse R783H mutation (R796H in human) altered Trim71’s mRNA substrate specificity and led to accelerated stem-cell differentiation and neural lineage commitment. [Embo Reports] AbstractGraphical Abstract