Pancreatic Cancer Cells Upregulate LPAR4 in Response to Isolation Stress To Promote an ECM-Enriched Niche and Support Tumour Initiation

Scientists reported that lysophosphatidic acid receptor 4 (LPAR4) became transiently upregulated on pancreatic cancer cells exposed to environmental stress or chemotherapy where it promoted stress tolerance, drug resistance, self-renewal, and tumour initiation.