Topical Application of Imatinib Mesylate Ameliorated Psoriasis-Like Skin Lesions in Imiquimod-Induced Murine Model via Angiogenesis Inhibition

Hyperproliferation of keratinocytes, hyperkeratosis, inflammatory cell infiltration and hypervascularity were histologically suppressed by topical imatinib mesylate. The expression of angiogenic factors including fibroblast growth factor and vascular endothelial growth factor was decreased.