NewslettersPancreatic Cell News MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression By Bob - March 21, 2023 0 In pancreatic neuroendocrine tumors cells resistant to everolimus, the downregulation of DCAF7 expression overcame resistance and synergized with everolimus to suppress mTOR activation and inhibit cancer cell growth. [Cancer Research] Abstract