NewslettersESC & iPSC NewsHematopoiesis News DNMT3A-Coordinated Splicing Governs the Stem State Switch towards Differentiation in Embryonic and Hematopoietic Stem Cells By Noshin Noorjahan - April 11, 2023 0 Investigators showed that stem state switch involved a global increase in splicing efficiency coordinated by DNA methyltransferase 3α (DNMT3A), an enzyme typically involved in DNA methylation. [Nature Cell Biology] Abstract