NewslettersImmunology of Infectious Disease News Macrophage ACE2 Is Necessary for SARS-CoV-2 Replication and Subsequent Cytokine Responses That Restrict Continued Virion Release By Bob - April 26, 2023 0 Investigators found that SARS-CoV-2 could enter, but did not replicate within, ACE2-deficient human primary macrophages and did not induce proinflammatory cytokine expression. [Science Signaling] Full Article