Mechanistically, macrophages mediated psoriasis via the Mincle-Syk-NF-κB pathway, as blocking macrophage Mincle inhibited Syk/NF-κB-driven skin lesions and epidermal injury in vivo and in vitro.
[Cell Death Discovery]
Macrophages Mediate Psoriasis via Mincle-Dependent Mechanism in Mice
